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Discovering novel immunotherapies through innovative translational research

Imaging Islet cellsThe immune system safeguards our bodies against infections and cancers, but also causes autoimmuine diseases and rejection of transplanted organs.  One of the fundamental properties of the immune system is the ability to regulate its own activities; this self-control prevents it from attacking healthy tissues and compels it to contract after successful elimination of the eliciting pathogens.  Our research seeks to better understand the mechanisms of immunoregulation, with the hopes of applying it to the prevention of transplant rejection and diabetes. 

Recent Publications

Tang Q, Kang SM
Interpretation of transplant biopsies and immune responses following Treg cell therapy.
Current opinion in organ transplantation, Dec-01-2014; 196: 616-20.
Lee RH, Roll G, Nguyen V, Willenbring H, Tang Q, Kang SM, Stock PG
Failure to achieve normal metabolic response in non-obese diabetic mice and streptozotocin-induced diabetic mice after transplantation of primary murine hepatocytes electroporated with the human proinsulin gene (p3MTChins).
Transplantation proceedings, 466: 2002-6.
Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC
Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.
Journal of immunology (Baltimore, Md. : 1950), Feb-15-2014; 1924: 1938-45.  Epub 2014 Jan 15.
Lee K, Nguyen V, Lee KM, Kang SM, Tang Q
Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Jan-01-2014; 141: 27-38.  Epub 2013 Nov 13.
Putnam AL, Safinia N, Medvec A, Laszkowska M, Wray M, Mintz MA, Trotta E, Szot GL, Liu W, Lares A, Lee K, Laing A, Lechler RI, Riley JL, Bluestone JA, Lombardi G, Tang Q
Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Nov-01-2013; 1311: 3010-20.  Epub 2013 Sep 18.
Tang Q, Bluestone JA
Regulatory T-cell therapy in transplantation: moving to the clinic.
Cold Spring Harbor perspectives in medicine, Nov-01-2013; [epublish] 311:.
Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC
Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice.
Blood, May-30-2013; 12122: 4595-602.  Epub 2013 Apr 22.
Tang Q, Leung J, Melli K, Lay K, Chuu EL, Liu W, Bluestone JA, Kang SM, Peddi VR, Vincenti F
Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipients.
Transplant international : official journal of the European Society for Organ Transplantation, Dec-01-2012; 2512: 1257-67.  Epub 2012 Sep 21.
Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Cell metabolism, Aug-08-2012; 162: 250-64.
Tang Q, Lee K
Regulatory T-cell therapy for transplantation: how many cells do we need?.
Current opinion in organ transplantation, Aug-01-2012; 174: 349-54.
Tang Q, Bluestone JA, Kang SM
CD4(+)Foxp3(+) regulatory T cell therapy in transplantation.
Journal of molecular cell biology, Feb-01-2012; 41: 11-21.  Epub 2011 Dec 14.
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